What is the new ZO Growth Factor Serum?
The ZO Growth Factor Serum is a reformulated advanced anti-ageing serum powered by bioengineered growth factor technology designed to mimic the skin's own natural signalling processes. Unlike the previous generation, which used plant- and enzymatically derived growth factors, this next-generation formula uses growth factors bioengineered to be human-comparable — working in alignment with the skin's biology to visibly improve density, firmness, elasticity, and smoothness. In clinical evaluation, participants reported skin that looked nearly 6 years younger after just 8 weeks of use.
What has changed in the reformulated ZO Growth Factor Serum?
The reformulation introduces bioengineered growth factor technology — a significant upgrade from the previous plant- and enzyme-derived growth factor approach. The new formula is designed to more closely replicate how the skin's own growth factors signal and communicate, resulting in more targeted support for skin repair and renewal. The clinical timeframe has also improved: the new formulation shows results that make skin appear nearly 6 years younger at 8 weeks, compared to the previous claim of up to 6 years younger at 12 weeks. The updated formula is also now suitable for use both morning and evening, rather than PM only.
Who should use the ZO Growth Factor Serum?
The Growth Factor Serum is suited to anyone experiencing visible signs of skin ageing, including loss of firmness and elasticity, fine lines and expression wrinkles, reduced skin density, or a dull and depleted complexion. It is appropriate for all skin types — including sensitive skin — and is particularly beneficial for those who want clinically proven, long-term anti-ageing results rather than surface-level hydration alone. It is a good fit both as a standalone anti-ageing serum and as part of a more comprehensive ZO Skin Health regimen.
How does the bioengineered growth factor technology in ZO Growth Factor Serum work?
Growth factors are proteins that naturally occur in the skin and act as messengers, instructing cells to repair, regenerate, and produce structural proteins like collagen and elastin. As skin ages, growth factor activity declines, which contributes to loss of firmness, texture, and density. The bioengineered growth factors in this reformulated serum are designed to mimic the skin's own growth factor signalling — supporting the skin's repair mechanisms and helping to restore the biological processes that keep skin looking youthful. The formula also includes ZPRO®, ZO's proprietary complex to help prevent future signs of ageing, and dipeptide diaminobutyroyl benzylamide diacetate to minimise the appearance of expression lines.
What are the key ingredients in the new ZO Growth Factor Serum?
The reformulated serum contains several clinically active ingredients working across multiple anti-ageing pathways. Bioengineered growth factor technology supports skin repair and renewal by mimicking the skin's natural signalling. ZPRO® is ZO's proprietary complex designed to help prevent future signs of ageing. Dipeptide diaminobutyroyl benzylamide diacetate minimises the appearance of expression lines. Disodium acetyl glucosamine phosphate and fermented red ginseng extract (lactobacillus/panax ginseng root extract ferment filtrate) work together to help restore hydration, elasticity, and firmness. Buddleja stem cell (Buddleja davidii meristem cell culture) helps protect against future signs of ageing. Beta glucan and angelica polymorpha sinensis root extract calm and soothe irritated skin. Panthenyl triacetate and glycerin support hydration and barrier reinforcement.
ow often should I use the ZO Growth Factor Serum and when in my routine?
The reformulated Growth Factor Serum is designed for twice-daily use — both morning and evening — which is a change from the previous PM-only recommendation. Cleanse your face with a mild cleanser and pat dry, then dispense a small amount onto fingertips and massage gently into skin using upward and outward strokes. Allow the serum to absorb for a few minutes before following with the rest of your routine. In the morning, follow with SPF as the final step. In the evening, follow with moisturiser or additional treatment products as directed.
What results can I expect from the ZO Growth Factor Serum, and how quickly?
The new formulation delivers measurable improvements across multiple areas of skin health. With consistent twice-daily use, you can expect improvements in skin firmness and elasticity, visible reduction in fine lines and expression wrinkles, improvements in skin density and thickness, restored hydration and a reinforced skin barrier. In clinical evaluation of the new formula, participants reported skin appearing nearly 6 years younger after 8 weeks of use — a notably faster result than the previous formulation's 12-week timeframe. As with all active serums, results build progressively, and consistent daily use is essential to maintain benefits.
How does the new ZO Growth Factor Serum differ from other anti-ageing serums?
The primary differentiator is the bioengineered growth factor technology — growth factors designed to mimic the skin's own biological signalling rather than relying on plant-derived analogues or generic peptide blends. This is a more targeted and sophisticated approach than most over-the-counter anti-ageing serums, which typically rely on surface-level antioxidants or hydrating peptides without addressing the deeper cellular signalling that drives skin repair. The addition of ZPRO® also gives the formula a preventative as well as corrective dimension, making it relevant across a wide age range. The formula is lightweight, suitable for all skin types including sensitive skin, and now designed for AM and PM use.
Is the ZO Growth Factor Serum safe for use around the eyes and on the neck?
The Growth Factor Serum is formulated for the face and neck, and is gentle enough for careful use in the periorbital area. The neck application is particularly relevant — as highlighted by ZO skincare experts, this serum is one of the recommended products for addressing the signs of ageing on the neck, where skin tends to be thinner and more vulnerable. For more targeted treatment of the eye contour specifically, ZO also offers the Growth Factor Eye Serum (0.5 fl. oz.), which is formulated and sized for the delicate eye area and pairs directly with this serum as a complementary step.
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Ageing skin
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